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Федеральный исследовательский центр 
«Красноярский научный центр
Сибирского отделения Российской академии наук»

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia

2019 год

Авторы
Freidin, M. B.
Tomsk NRMC, Res Inst Med Genet, 10 Nab Ushaiki, Tomsk 634050, Russia.
Barilo, A. A.
Sci Res Inst Med Problems North, Krasnoyarsk, Russia.
Smolnikova, M. V.
Sci Res Inst Med Problems North, Krasnoyarsk, Russia.
Smirnova, S. V.
Russian Acad Med Sci, State Med Res Inst Northern Problems, Krasnoyarsk, Russia.
Psoriasis (PS) and psoriatic arthritis (PsA) are subtypes of psoriatic disease (PD), a chronic inflammatory disorder with predominantly cutaneous manifestations. PsA is developed in approximately one third of patients with PS. These two phenotypes are immune-mediated diseases with different heredity that might in part be explained by different genetic factors. We carried out an analysis of association between haplotypes of cytokine genes (TNFA, IL4 and IL10) and PD in Russians from East Siberian region of Russia. The haplotypes were not found to be associated with either PS or PsA. However, meta-analyses with published data suggested associations between PS and IL4 rs2243250 and TNFA rs1800629 polymorphisms, while PsA was found to be associated with IL4 rs2243250 only. The results provide further insight into understanding of genetic factors predisposing to PD. © 2018


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